Humans have a large variability in body fat distribution, which has tremendous implications for metabolic health. Obese individuals with an upper-body-fat distribution have increased health complications such as dyslipidemia, hypertension, insulin resistance, and type 2 diabetes in comparison with lower-body-obese individuals. Additionally, females have more body fat, a greater proportion of fat in their lower body, and much less visceral fat than do lean males at the same body mass index. The reasons for these differences in body fat distribution have not been clearly identified but could be important. Herein we review what has been learned about regional differences in triglyceride storage capacity and lipolysis as they relate to the causes and consequences of regional fat accumulation. Both sex and site differences in regional fat storage have been described. In contrast, with the exception of variations between men and women in the contribution of visceral adipose tissue to hepatic FFA delivery, most studies have failed to show important sex differences in regional lipolysis in vivo.

中文翻译：

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区域性脂肪沉积是FFA代谢的一个因素。

人类的体内脂肪分布变化很大，这对代谢健康具有重大影响。与下身肥胖者相比，具有上身脂肪分布的肥胖个体的健康并发症增加，例如血脂异常，高血压，胰岛素抵抗和2型糖尿病。此外，在相同的体重指数下，女性的体脂肪比瘦男性的身体脂肪更多，下半部分的脂肪比例更高，内脏脂肪更少。这些体内脂肪分布差异的原因尚不清楚，但可能很重要。本文中，我们回顾了有关甘油三酸酯储存能力和脂解作用的区域差异的已知知识，因为它们与区域脂肪堆积的原因和后果相关。已经描述了区域脂肪储存中的性别和部位差异。相比之下，除了内脏脂肪组织对肝脏FFA输送的贡献方面男女之间的差异外，大多数研究未能显示出体内区域性脂解的重要性别差异。