Injury to the skin initiates a complex process of events involving inflammation as well as the formation and remodeling of new tissue. These processes result in at least partial reconstitution of the injured skin. However, wounds in adult mammals heal with a scar, which is accompanied by functional and aesthetic impairments. In addition to this problem, a large number of patients, in particular in the aged population, suffer from chronic, nonhealing ulcers. Therefore, there is a strong need to improve the wound healing process. This requires a thorough understanding of the underlying molecular and cellular mechanisms. During the past several years, important regulators of the wound healing process have been identified. In particular, the growth factors and matrix proteins, which orchestrate skin repair, have been characterized in detail. By contrast, much less is known about the transcription factors, which regulate gene expression at the wound site. This review summarizes recent data on the expression of transcription factors in skin wounds and their functions in the repair process.

中文翻译：

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伤口修复的转录控制。

皮肤损伤会引发复杂的事件，包括炎症以及新组织的形成和重塑。这些过程导致受伤的皮肤至少部分重建。但是，成年哺乳动物的伤口愈合后会留下疤痕，并伴有功能和美学上的损害。除了这个问题，许多患者，特别是在老年人中，患有慢性，不愈合的溃疡。因此，强烈需要改善伤口愈合过程。这需要彻底了解潜在的分子和细胞机制。在过去的几年中，已经确定了伤口愈合过程的重要调节剂。特别地，已经详细表征了调节皮肤修复的生长因子和基质蛋白。相比之下，人们对转录因子的了解还很少，转录因子调节伤口部位的基因表达。这篇综述总结了有关皮肤伤口中转录因子的表达及其在修复过程中的功能的最新数据。