Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of tissues. To investigate these roles and exploit them for tissue engineering or to overcome barriers to drug delivery, a comprehensive consideration of the interstitial space and how it controls and affects such processes is critical. Here we attempt to review the many physical and mathematical correlations that describe fluid and mass transport in the tissue interstitium; the factors that control and affect them; and the importance of interstitial transport on cell biology, tissue morphogenesis, and tissue engineering. Finally, we end with some discussion of interstitial transport issues in drug delivery, cell mechanobiology, and cell homing toward draining lymphatics.

中文翻译：

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间隙流动及其在软组织中的作用。

间隙流动在组织的形态发生，功能和发病机理中起重要作用。为了研究这些作用并将其用于组织工程或克服药物输送的障碍，对间隙空间及其如何控制和影响这种过程的全面考虑至关重要。在这里，我们试图回顾许多描述组织间质中流体和质量传输的物理和数学关系。控制和影响他们的因素；以及间隙运输对细胞生物学，组织形态发生和组织工程的重要性。最后，我们以药物输送，细胞力学生物学和细胞向引流淋巴管的归巢中的间质运输问题作一些讨论。