Anorexia nervosa is a perplexing illness marked by low body weight and persistent fear of weight gain. Anorexia nervosa has the highest mortality rate of any psychiatric disease. Historically, anorexia nervosa was viewed as a disorder primarily influenced by sociocultural factors; however, over the past decade, this perception has been challenged. Family studies have consistently demonstrated that anorexia nervosa runs in families. Twin studies have underscored the contribution of additive genetic factors to the observed familial aggregation. With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research.

中文翻译：

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神经性厌食症的遗传学。

神经性厌食症是一种以低体重和持续担心体重增加为特征的令人困惑的疾病。神经性厌食症是所有精神疾病中死亡率最高的。从历史上看，神经性厌食症被认为是一种主要受社会文化因素影响的疾病。然而，在过去的十年中，这种看法受到了挑战。家庭研究一直表明，神经性厌食症在家庭中存在。两项研究强调了附加遗传因素对所观察到的家族聚集的贡献。以这些文献为出发点，我们严格评估神经性厌食症的分子遗传学研究的现状，并为今后的研究提供指导。