The mammalian central nervous system (CNS) requires the proper formation of exquisitely precise circuits to function correctly. These neuronal circuits are assembled during development by the formation of synaptic connections between thousands of differentiating neurons. Proper synapse formation during childhood provides the substrate for cognition, whereas improper formation or function of these synapses leads to neurodevelopmental disorders, including mental retardation and autism. Recent work has begun to identify some of the early cellular events in synapse formation as well as the molecular signals that initiate this process. However, despite the wealth of information published on this topic in the past few years, some of the most fundamental questions about how, whether, and where glutamatergic synapses form in the mammalian CNS remain unanswered. This review focuses on the dynamic aspects of the early cellular and molecular events in the initial assembly of glutamatergic synapses in the mammalian CNS.

中文翻译：

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CNS 突触形成的动态方面。


哺乳动物的中枢神经系统 (CNS) 需要正确形成极其精确的电路才能正常运行。这些神经元回路在发育过程中通过在数千个分化神经元之间形成突触连接来组装。儿童时期正确的突触形成为认知提供了基础，而这些突触的不正确形成或功能会导致神经发育障碍，包括智力低下和自闭症。最近的工作已经开始识别突触形成中的一些早期细胞事件以及启动该过程的分子信号。然而，尽管过去几年关于这一主题发表了大量信息，但关于哺乳动物中枢神经系统中谷氨酸突触如何、是否以及在何处形成的一些最基本的问题仍未得到解答。本综述重点关注哺乳动物中枢神经系统谷氨酸能突触初始组装过程中早期细胞和分子事件的动态方面。