Potential safety issues have been raised with the development and release of virus-resistant transgenic plants. This review focuses on safety assessment with a special emphasis on crops that have been commercialized or extensively tested in the field such as squash, papaya, plum, grape, and sugar beet. We discuss topics commonly perceived to be of concern to the environment and to human health--heteroencapsidation, recombination, synergism, gene flow, impact on nontarget organisms, and food safety in terms of allergenicity. The wealth of field observations and experimental data is critically evaluated to draw inferences on the most relevant issues. We also express inside views on the safety and benefits of virus-resistant transgenic plants, and recommend realistic risk assessment approaches to assist their timely deregulation and release.

中文翻译：

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抗病毒转基因植物被引入的二十年后的安全性：来自实际田间风险评估研究的经验教训。

随着抗病毒转基因植物的发展和释放，已经提出了潜在的安全问题。这篇综述着重于安全性评估，特别着重于已在该领域进行商业化或广泛测试的农作物，例如南瓜，木瓜，李子，葡萄和甜菜。我们讨论了通常被认为与环境和人类健康有关的主题-异化衣壳，重组，增效作用，基因流动，对非目标生物的影响以及就过敏原而言的食品安全性。对大量的现场观测和实验数据进行了严格的评估，以推断出最相关的问题。我们还对抗病毒转基因植物的安全性和益处发表内部看法，并建议现实的风险评估方法，以帮助其及时解除管制和释放。