The pathogenesis of AIDS has proven to be quite complex and dynamic, with most of the critical events (e.g., transmission, CD4(+) T cell destruction) occurring in tissues that are not easily accessible for analysis. In addition, although the disease can progress over years, many critical events happen within the first few weeks of infection, when most patients are unaware that they are infected. The nonhuman primate model of AIDS has been used extensively to fill these gaps in our understanding of AIDS pathogenesis.

中文翻译：

---

艾滋病发病机理的最新概念：SIV /猕猴模型的见解。

艾滋病的发病机制已被证明是非常复杂和动态的，大多数关键事件（例如传播，CD4（+）T细胞破坏）发生在难以进行分析的组织中。此外，尽管这种疾病可以持续数年发展，但在大多数感染者不知道自己感染了病毒的最初几周内，还是会发生许多严重事件。AIDS的非人类灵长类动物模型已广泛用于填补我们对AIDS发病机理的了解中的这些空白。