Discovery of a large family of Fc receptor-like (FCRL) molecules, homologous to the well-known receptors for the Fc portion of immunoglobulin (FCR), has uncovered an impressive abundance of immunoglobulin superfamily (IgSF) genes in the human 1q21-23 chromosomal region and revealed significant diversity for these genes between humans and mice. The observation that FCRL representatives are members of an ancient multigene family that share a common ancestor with the classical FCR is underscored by their linked genomic locations, gene structure, shared extracellular domain composition, and utilization of common cytoplasmic tyrosine-based signaling elements. In contrast to the conventional FCR, however, FCRL molecules possess diverse extracellular frameworks, autonomous or dual signaling properties, and preferential B lineage expression. Most importantly, there is no strong evidence thus far to support a role for them as Ig-binding receptors. These characteristics, in addition to their identification in malignancies and autoimmune disorders, predict a fundamental role for these receptors as immunomodulatory agents in normal and subverted B lineage cells.

中文翻译：

---

Fc 受体样分子。


发现一大类 Fc 受体样 (FCRL) 分子，与众所周知的免疫球蛋白 (FCR) Fc 部分受体同源，在人类 1q21-23 中发现了大量的免疫球蛋白超家族 (IgSF) 基因染色体区域并揭示了人类和小鼠之间这些基因的显着多样性。 FCRL 代表是与经典 FCR 具有共同祖先的古老多基因家族的成员，这一观察结果强调了它们相关的基因组位置、基因结构、共享的细胞外结构域组成以及共同的基于细胞质酪氨酸的信号元件的利用。然而，与传统的 FCR 相比，FCRL 分子具有不同的细胞外框架、自主或双重信号传导特性以及优先的 B 谱系表达。最重要的是，迄今为止没有强有力的证据支持它们作为 Ig 结合受体的作用。这些特征，除了在恶性肿瘤和自身免疫性疾病中的识别之外，还预测了这些受体作为正常和颠覆的 B 谱系细胞中的免疫调节剂的基本作用。