Small lipophilic molecules such as steroidal hormones, retinoids, and free fatty acids control many of the reproductive, developmental, and metabolic processes in eukaryotes. The mediators of these effects are nuclear receptor proteins, ligand-activated transcription factors capable of regulating the expression of complex gene networks. This review addresses the structure and structural properties of nuclear receptors, focusing on the well-studied ligand-binding and DNA-binding domains as well as our still-emerging understanding of the largely unstructured N-terminal regions. To emphasize the allosteric interdependence among these subunits, a more detailed inspection of the structural properties of the human progesterone receptor is presented. Finally, this work is placed in the context of developing a quantitative and mechanistic understanding of nuclear receptor function.

中文翻译：

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核受体结构：对功能的影响。

诸如类固醇激素，类维生素A和游离脂肪酸之类的亲脂小分子控制着真核生物的许多生殖，发育和代谢过程。这些作用的介质是核受体蛋白，即能够调节复杂基因网络表达的配体激活的转录因子。这项审查解决核受体的结构和结构特性，侧重于研究充分的配体结合和DNA结合域，以及我们对大部分非结构化的N末端区域的新兴知识。为了强调这些亚基之间的变构相互依赖性，提出了对人类孕激素受体的结构特性的更详细的检查。最后，