This review examines the connections between circadian and metabolic rhythms. Examples from a wide variety of well-studied organisms are used to illustrate some of the genetic and molecular pathways linking circadian timekeeping to metabolism. The principles underlying biological timekeeping by intrinsic circadian clocks are discussed briefly. Genetic and molecular studies have unambiguously identified the importance of gene expression feedback circuits to the generation of overt circadian rhythms. This is illustrated particularly well by the results of genome-wide expression studies, which have uncovered hundreds of clock-controlled genes in cyanobacteria, fungi, plants, and animals. The potential connections between circadian oscillations in gene expression and circadian oscillations in metabolic activity are a major focus of this review.

中文翻译：

---

昼夜节律时钟和新陈代谢节律的相互作用。

这项审查审查了昼夜节律和代谢节律之间的联系。来自各种各样经过深入研究的生物的例子被用来说明将昼夜节律与新陈代谢联系起来的一些遗传和分子途径。简要讨论了通过内在的生物钟进行生物计时的原理。遗传和分子研究已明确确定基因表达反馈回路对产生明显的昼夜节律的重要性。全基因组表达研究的结果特别说明了这一点，该研究已经发现了蓝细菌，真菌，植物和动物中数百种受时钟控制的基因。基因表达的昼夜节律振荡与代谢活动中的昼夜节律振荡之间的潜在联系是本综述的主要重点。