Iron is needed by all mammalian cells but is toxic in excess. Specialized transport mechanisms conduct iron across cellular membranes. These are regulated to ensure homeostasis both systemically in living organisms and within individual cells. Over the past decade, major advances have been made in identifying and characterizing the proteins involved in the transport, handling, and homeostatic regulation of iron. Molecular understanding of these processes has provided important insights into the pathophysiology of human iron disorders.

中文翻译：

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铁稳态。

所有哺乳动物细胞都需要铁，但铁的毒性过大。专门的运输机制将铁跨细胞膜传导。这些被调节以确保体内生物体内和单个细胞内的体内稳态。在过去的十年中，在鉴定和表征与铁的运输，处理和体内稳态调节有关的蛋白质方面取得了重大进展。对这些过程的分子理解为人类铁疾病的病理生理学提供了重要的见识。