Over the past decade there has been considerable progress in elucidating the signaling pathways involved in cardioprotection. Considerable recent data suggest that many of these signaling pathways converge on the mitochondria, where such pathways alter the activity of key mitochondrial proteins, leading to reduced apoptosis and necrosis. Inhibition of the mitochondrial permeability transition pore is emerging as a central mechanism in cardioprotection. This review focuses on mechanisms by which cardioprotection alters mitochondrial proteins and channels that regulate cell death and survival.

中文翻译：

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预处理：线粒体连接。

在过去的十年中，在阐明涉及心脏保护的信号途径方面取得了长足的进步。最新的大量数据表明，这些信号传导途径中有许多汇聚在线粒体上，这些途径改变了关键的线粒体蛋白的活性，从而导致细胞凋亡和坏死的减少。线粒体通透性过渡孔的抑制作用正在成为心脏保护的主要机制。这项审查侧重于心脏保护作用改变线粒体蛋白和调节细胞死亡和存活的通道的机制。