The unabated rise in the prevalence of obesity is a challenge for global health care systems. Efforts to reverse this trend by dietary or behavioral counseling have not been successful, which has stimulated efforts to find a role for pharmacotherapy. Currently only a small number of antiobesity drugs are approved for long-term use and only a few compounds are in clinical development. Despite recent progress in the understanding of the regulation of energy balance, drug discovery has been less productive than expected. In the present review, the clinically available antiobesity agents are discussed. Examples of drug candidates that are currently in development are given and the possible future range of antiobesity agents is illustrated by the targets being addressed in drug discovery. Finally, the efficacy of antiobesity agents and their value in the treatment of obesity are assessed in comparison with other therapeutic approaches, such as surgery and changes in lifestyle.

中文翻译：

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肥胖病流行：目前和将来的药物治疗。

肥胖症患病率的持续增长对全球卫生保健系统构成了挑战。通过饮食或行为咨询来逆转这种趋势的努力并未取得成功，这刺激了寻找药物治疗作用的努力。目前，只有少量的抗肥胖药被批准可长期使用，并且仅有少数化合物正在临床开发中。尽管在了解能量平衡的调节方面取得了最新进展，但是药物发现的生产率却低于预期。在本综述中，讨论了临床上可用的减肥药。给出了目前正在研发中的候选药物的实例，并通过药物发现中所针对的目标来说明抗肥胖药的未来可能范围。最后，