Many different types of radiation have been exploited to provide images of the structure and function of tissues inside a living subject. Each imaging modality is characterized by differing resolutions on the spatial and temporal scales, and by a different sensitivity for measuring properties related to morphology or function. Combinations of imaging modalities that integrate the strengths of two modalities, and at the same time eliminate one or more weaknesses of an individual modality, thus offer the prospect of improved diagnostics, therapeutic monitoring, and preclinical research using imaging approaches. This review discusses the advantages and challenges in developing multimodality imaging systems for in vivo use, highlights some successful combinations that are now routinely used in the clinic and in research, and discusses recent advances in multimodality instrumentation that may offer new opportunities for imaging.

中文翻译：

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体内成像系统的多模态：功率加倍还是麻烦加倍？

已经开发出许多不同类型的辐射来提供活体内部组织的结构和功能的图像。每个成像模态的特征是在空间和时间尺度上具有不同的分辨率，并且具有用于测量与形态或功能有关的特性的不同灵敏度。结合了两种模态优势的成像模态组合，同时消除了单个模态的一个或多个弱点，因此提供了使用成像方法改善诊断，治疗监测和临床前研究的前景。这篇评论讨论了开发用于体内使用的多模态成像系统的优势和挑战，重点介绍了目前在临床和研究中常规使用的一些成功组合，