Fortunately, I began research in 1950 when the basic concepts of microbial genetics could be explored experimentally. I began with bacteriophage lambda and tried to establish the colinearity of its linkage map with its DNA molecule. My students and I worked out the regulation of lambda repressor synthesis for the establishment and maintenance of lysogeny. We also investigated the proteins responsible for assembly of the phage head. Using cell extracts, we discovered how to package DNA inside the head in vitro. Around 1972, I began to use molecular genetics to understand the developmental biology of Myxococcus xanthus. In particular, I wanted to learn how myxococcus builds its multicellular fruiting body within which it differentiates spores. We identified two cell-to-cell signals used to coordinate development. We have elucidated, in part, the signal transduction pathway for C-signal that directs the morphogenesis of a fruiting body.

中文翻译：

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微生物遗传之旅。

幸运的是，我于1950年开始研究，当时可以通过实验探索微生物遗传学的基本概念。我从噬菌体λ开始，试图建立其连锁图与其DNA分子的共线性。我和我的学生们研究了λ抑制子合成的调控，以建立和维持溶原性。我们还研究了负责噬菌体头组装的蛋白质。使用细胞提取物，我们发现了如何在体外将DNA包装在头部内部。1972年左右，我开始使用分子遗传学来了解黄色粘球菌的发育生物学。特别是，我想学习粘球菌如何建立其多细胞子实体，从而在其中分化孢子。我们确定了两个用于协调发展的细胞间信号。我们已经部分阐明了