The present study provides evidence for a correlation between the brain-associated stem cell antigen and the self-renewal capacity of pluripotent hematopoietic stem cells (spleen colony-forming units). A minor subpopulation of spleen colony-forming units which does not express the antigen exhibited a 3- to 4-fold greater self-renewal capacity while proliferating in both bone marrow and spleen compared to stem cells which express the antigen. This finding supports the 'generation-age' hypothesis for stem cell differentiation; according to this hypothesis, hematopoietic cells derive from a population of young stem cells which lack the antigen, exhibit a high self-renewal capacity, and are quiescent in cell cycle.

中文翻译：

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小鼠造血干细胞亚群自我更新能力不同的免疫学证据。

本研究为脑相关干细胞抗原与多能造血干细胞（脾集落形成单位）的自我更新能力之间的相关性提供了证据。与表达抗原的干细胞相比，不表达抗原的脾脏集落形成单位的较小亚群在骨髓和脾脏中均增殖了3-4倍的自我更新能力，同时在骨髓和脾脏中均增殖。这一发现支持了干细胞分化的“一代时代”假说。根据该假设，造血细胞源自缺乏抗原，具有高自我更新能力并且在细胞周期中处于静止状态的年轻干细胞群体。