The field of neurotrophins, particularly, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), has witnessed a number of breakthroughs in recent years. There is evidence now that NGF and BDNF mediate multiple biological phenomena, ranging from the Rita Levi Montalcini's neurotrophic through immunotrophic to epitheliotrophic and nociceptive effects. In 2003 we, for the first time, enriched the "NGFome" with one more expression presented in our concept of NGF metabotrophicity, also that of BDNF. This envisages that these two factors may operate as metabotrophins, that is, involved in the maintenance of cardiometabolic homeostasis (glucose and lipid metabolism as well as energy balance, cardioprotection, and wound healing). Recent results also demonstrated that the circulating and/or tissue levels of NGF and BDNF are altered in cardiometabolic diseases (atherosclerosis, obesity, type 2 diabetes, metabolic syndrome, and type 3 diabetes). Altogether, a hypothesis of metabotrophic deficit due to the reduction of NGF/BDNF availability and/or utilization was raised, and implicated in the pathogenesis of cardiometabolic diseases. This may cultivate a novel pathogenic and therapeutic thinking for these diseases.

中文翻译：

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代谢型NGF和BDNF：一个新兴概念。

近年来，神经营养蛋白领域，尤其是神经生长因子（NGF）和脑源性神经营养因子（BDNF）取得了许多突破。现在有证据表明NGF和BDNF介导多种生物学现象，从Rita Levi Montalcini的神经营养到免疫营养，再到上皮营养和伤害感受。2003年，我们首次丰富了我们的NGF代谢型概念，也包括BDNF的一个概念，丰富了“ NGFome”。设想这两个因素可以作为代谢型促生物素起作用，即参与维持心脏代谢稳态（葡萄糖和脂质代谢以及能量平衡，心脏保护和伤口愈合）。最近的结果还表明，在心脏代谢疾病（动脉粥样硬化，肥胖症，2型糖尿病，代谢综合征和3型糖尿病）中，NGF和BDNF的循环和/或组织水平发生了改变。总而言之，提出了一种由于NGF / BDNF利用率和/或利用率降低而引起的营养缺陷型假说，并与心脏代谢疾病的发病机制有关。这可以为这些疾病培养新的病原学和治疗学思路。