An improved synthesis of a water-soluble deep-cavity cavitand (octa-acid, 1) is presented. Previously (Gibb, C.L.D.; Gibb, B.C. J. Am. Chem. Soc. 2004, 126, 11408–11409), we documented access to host 1 in eight (non-linear) steps starting from resorcinol; a synthesis that required four steps involving chromatographic purification. Here, we reveal a modified synthesis of host 1. Consisting of seven (non-linear) steps, this new synthesis involves only one chromatographic step, and avoids a minor impurity observed in the original approach. This improved synthesis is therefore useful for the laboratories that are investigating the properties of these types of host.

中文翻译：

---

一种改进的“八酸”深腔腔体的合成

提出了一种改进的水溶性深腔空腔 (octa-acid, 1) 合成方法。以前 (Gibb, CLD; Gibb, BCJ Am. Chem. Soc. 2004, 126, 11408–11409)，我们记录了从间苯二酚开始的八步（非线性）步骤中对宿主 1 的访问；合成需要四个步骤，包括色谱纯化。在这里，我们揭示了宿主 1 的改进合成。由七个（非线性）步骤组成，这种新的合成仅涉及一个色谱步骤，并且避免了在原始方法中观察到的少量杂质。因此，这种改进的合成对于正在研究这些类型宿主特性的实验室很有用。