BACKGROUND Both early alcohol debut, behavioural and health problems are reported to enhance adolescence substance use. This prospective study investigate the influence of behavioural and health problems on adolescents' alcohol and drug use. METHOD Prospective population based cohort study of 2 399 adolescents attending the Young-HUNT study, aged 13-15 at baseline in 1995/97, and 17-19 at follow-up 4 years later. Exposure variables were self reported conduct problems, attention problems, anxiety and depressive symptoms, and muscular pain and tension. Outcome variables at follow-up were frequent alcohol use and initiation of drug use. Associations were estimated by logistic regression models, influence of gender and drinking status at baseline were controlled for by stratification. RESULTS At follow-up 19% of the students drank alcohol once a week or more frequently. Baseline conduct problems (OR 2.2, CI 1.7-3.0) and attention problems (OR 1.5, CI 1.2-2.0) increased the risk for frequent alcohol use at follow-up in the total population. Girls who had experienced alcohol-intoxications at baseline showed strong association between baseline problems and frequent alcohol use at follow-up. Conduct problems (OR 2.5, CI 1.3-4.8), attention problems (OR 2.1, CI 1.2-3.4), anxiety/depressive symptoms (OR 1.9, CI 1.1-3.1) and muscular pain and tension (OR 1.7, CI 1.0-2.9) all were associated with frequent alcohol use among early intoxicated girls.14% of the students had tried cannabis or other drugs at follow-up. Conduct problems at baseline increased the odds for drug use (OR 2.6, CI 1.9-3.6). Any alcohol intoxications at baseline, predicted both frequent alcohol use (boys OR 3.6, CI 2.4-5.2; girls OR 2.8, CI 1.9-4.1), and illegal drug use (boys OR 4.7; CI 3.2-7.0, girls OR 7.7, CI 5.2-11.5) within follow-up. CONCLUSIONS Conduct problems in high-school more than doubles the risk for both frequent alcohol use and initiation of drug use later in adolescence. The combination of health problems and alcohol intoxication in early adolescence was closely associated with more frequent drinking later in adolescence among girls.Overall, early alcohol intoxication was closely associated with both frequent alcohol use and drug use at follow up in both genders.

中文翻译：

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行为和健康问题对青春期后期酒精和药物使用的影响——对 2 399 名挪威青年的后续研究。

背景 据报道，早期饮酒、行为和健康问题都会增加青少年对物质的使用。这项前瞻性研究调查了行为和健康问题对青少年饮酒和吸毒的影响。方法 基于人群的前瞻性队列研究，纳入 Young-HUNT 研究的 2399 名青少年，1995/97 年基线年龄为 13-15 岁，4 年后随访时为 17-19 岁。暴露变量是自我报告的行为问题、注意力问题、焦虑和抑郁症状，以及肌肉疼痛和紧张。随访结果变量是频繁饮酒和开始吸毒。通过逻辑回归模型估计关联，基线时性别和饮酒状态的影响通过分层控制。结果 在随访中，19% 的学生每周饮酒一次或更频繁。基线行为问题（OR 2.2，CI 1.7-3.0）和注意力问题（OR 1.5，CI 1.2-2.0）增加了整个人群随访时频繁饮酒的风险。在基线时经历过酒精中毒的女孩在基线问题和随访时经常饮酒之间表现出很强的关联。行为问题（OR 2.5，CI 1.3-4.8），注意力问题（OR 2.1，CI 1.2-3.4），焦虑/抑郁症状（OR 1.9，CI 1.1-3.1）以及肌肉疼痛和紧张（OR 1.7，CI 1.0-2.9） ) 所有这些都与早期醉酒女孩的频繁饮酒有关。14% 的学生在随访中尝试过大麻或其他药物。基线行为问题增加了吸毒的几率（OR 2.6，CI 1.9-3.6）。基线时的任何酒精中毒，预测了频繁饮酒（男孩 OR 3.6，CI 2.4-5.2；女孩 OR 2.8，CI 1.9-4.1）和非法吸毒（男孩 OR 4.7；CI 3.2-7.0，女孩 OR 7.7，CI 5.2-11.5） -向上。结论 高中时期的品行问题会使频繁饮酒和在青春期后期开始吸毒的风险增加一倍以上。青春期早期的健康问题和酒精中毒的结合与女孩青春期后期更频繁的饮酒密切相关。总的来说，早期酒精中毒与两性的频繁饮酒和随访时的药物使用密切相关。结论 高中时期的品行问题会使频繁饮酒和在青春期后期开始吸毒的风险增加一倍以上。青春期早期的健康问题和酒精中毒的结合与女孩青春期后期更频繁的饮酒密切相关。总的来说，早期酒精中毒与两性的频繁饮酒和随访时的药物使用密切相关。结论 高中时期的品行问题会使频繁饮酒和在青春期后期开始吸毒的风险增加一倍以上。青春期早期的健康问题和酒精中毒的结合与女孩青春期后期更频繁的饮酒密切相关。总的来说，早期酒精中毒与两性的频繁饮酒和随访时的药物使用密切相关。