A minimally invasive electrical recording and stimulating technique capable of simultaneously monitoring the activity of a significant number (e.g., 10³ to 10⁴) of neurons is an absolute prerequisite in developing an effective brain–machine interface. Although there are many excellent methodologies for recording single or multiple neurons, there has been no methodology for accessing large numbers of cells in a behaving experimental animal or human individual. Brain vascular parenchyma is a promising candidate for addressing this problem. It has been proposed [1, 2] that a multitude of nanowire electrodes introduced into the central nervous system through the vascular system to address any brain area may be a possible solution. In this study we implement a design for such microcatheter for ex vivo experiments. Using Wollaston platinum wire, we design a submicron‐scale electrode and develop a fabrication method. We then evaluate the mechanical properties of the electrode in a flow when passing through the intricacies of the capillary bed in ex vivo Xenopus laevis experiments. Furthermore, we demonstrate the feasibility of intravascular recording in the spinal cord of Xenopus laevis. © 2009 Wiley Periodicals, Inc. Electron Comm Jpn, 92(7): 29–37, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10058

中文翻译：

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具有纳米线电极的血管内神经接口。

一种微创电记录和刺激技术，能够同时监测大量（例如，10 ³至 10 ⁴) 的神经元是开发有效脑机接口的绝对先决条件。尽管有许多优秀的方法可以记录单个或多个神经元，但还没有方法可以访问行为实验动物或人类个体的大量细胞。脑血管实质是解决这个问题的有希望的候选者。已经提出 [1, 2] 将大量纳米线电极通过血管系统引入中枢神经系统以处理任何大脑区域可能是一种可能的解决方案。在这项研究中，我们为这种体外微导管设计实验。我们使用 Wollaston 铂丝设计了亚微米级电极并开发了一种制造方法。然后，我们在体外非洲爪蟾实验中通过错综复杂的毛细血管床时评估电极在流动中的机械性能。此外，我们证明了在非洲爪蟾脊髓中进行血管内记录的可行性。© 2009 Wiley Periodicals, Inc. Electron Comm Jpn, 92(7): 29–37, 2009; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/ecj.10058