Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.

中文翻译：

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量化鸡胚胎心脏流出道中的血流和壁切应力

血流对心脏组织施加的壁切应力 (WSS) 调节心脏的生长和发育。为了研究血液动力学条件对心脏形态发生的作用，在这里，我们提出了一种结合成像和有限元建模的方法来量化早期鸡胚胎（第 3 天）心脏流出道 (OFT) 中的体内血流动力学和 WSS 21 天的潜伏期）。我们在鸡胚胎心脏 OFT 中发现了明显的血流场和 WSS 的异质分布，这对 OFT 的形态发生具有生理意义。