A comprehensive neuropsychological/psychiatric, MR imaging, (MRI), MR spectroscopy (MRS), and functional MRI (fMRI) assessment was administered to children with fetal alcohol spectrum disorders (FASD) to determine if global and/or focal abnormalities could be identified, and distinguish diagnostic subclassifications across the spectrum. The four study groups included: 1. FAS/Partial FAS; 2. Static Encephalopathy/Alcohol Exposed (SE/AE); 3. Neurobehavioral Disorder/Alcohol Exposed (ND/AE); and 4. healthy peers with no prenatal alcohol exposure. fMRI outcomes are reported here. The neuropsychological/psychiatric, MRI, and MRS outcomes are reported separately. fMRI was used to assess activation in seven brain regions during performance of N-back working memory tasks. Children across the full spectrum of FASD exhibited significant working memory deficits and altered activation patterns in brain regions that are known to be involved in working memory. These results demonstrate the potential research and diagnostic value of this non-invasive MR tool in the field of FASD.

中文翻译：

---

对胎儿酒精谱系障碍儿童进行全面磁共振研究的功能磁共振成像结果。

对患有胎儿酒精谱系障碍 (FASD) 的儿童进行了全面的神经心理学/精神病学、MR 成像 (MRI)、MR 波谱 (MRS) 和功能性 MRI (fMRI) 评估，以确定是否可以识别整体和/或局灶性异常，并在整个范围内区分诊断子分类。四个研究组包括： 1. FAS/部分 FAS；2. 静态脑病/酒精暴露（SE/AE）；3. 神经行为障碍/酒精暴露（ND/AE）；4. 没有产前酒精暴露的健康同龄人。此处报告了 fMRI 结果。神经心理学/精神病学、MRI 和 MRS 结果分别报告。fMRI 用于评估在执行 N-back 工作记忆任务期间七个大脑区域的激活。整个 FASD 范围内的儿童都表现出显着的工作记忆缺陷，并且已知参与工作记忆的大脑区域的激活模式发生了改变。这些结果证明了这种非侵入性 MR 工具在 FASD 领域的潜在研究和诊断价值。