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Molecular motors: directing traffic during RNA localization.
Critical Reviews in Biochemistry and Molecular Biology ( IF 6.2 ) Pub Date : 2011-04-11 , DOI: 10.3109/10409238.2011.572861
James A Gagnon 1 , Kimberly L Mowry
Affiliation  

RNA localization, the enrichment of RNA in a specific subcellular region, is a mechanism for the establishment and maintenance of cellular polarity in a variety of systems. Ultimately, this results in a universal method for spatially restricting gene expression. Although the consequences of RNA localization are well-appreciated, many of the mechanisms that are responsible for carrying out polarized transport remain elusive. Several recent studies have illuminated the roles that molecular motor proteins play in the process of RNA localization. These studies have revealed complex mechanisms in which the coordinated action of one or more motor proteins can act at different points in the localization process to direct RNAs to their final destination. In this review, we discuss recent findings from several different systems in an effort to clarify pathways and mechanisms that control the directed movement of RNA.

中文翻译:

分子马达:在 RNA 定位期间引导交通。

RNA 定位,即特定亚细胞区域中 RNA 的富集,是在各种系统中建立和维持细胞极性的机制。最终,这产生了一种用于空间限制基因表达的通用方法。尽管 RNA 定位的后果广为人知,但许多负责执行极化运输的机制仍然难以捉摸。最近的几项研究阐明了分子运动蛋白在 RNA 定位过程中的作用。这些研究揭示了复杂的机制,其中一种或多种运动蛋白的协调作用可以在定位过程中的不同点起作用,以将 RNA 引导到它们的最终目的地。在这次审查中,
更新日期:2019-11-01
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