Intravascular photoacoustic (IVPA) imaging is a catheter-based, minimally invasive, imaging modality capable of providing high-resolution optical absorption map of the arterial wall. Integrated with intravascular ultrasound (IVUS) imaging, combined IVPA and IVUS imaging can be used to detect and characterize atherosclerotic plaques building up in the inner lining of an artery. In this paper, we present and discuss various representative applications of combined IVPA/IVUS imaging of atherosclerosis, including assessment of the composition of atherosclerotic plaques, imaging of macrophages within the plaques, and molecular imaging of biomarkers associated with formation and development of plaques. In addition, imaging of coronary artery stents using IVPA and IVUS imaging is demonstrated. Furthermore, the design of an integrated IVUS/IVPA imaging catheter needed for in vivo clinical applications is discussed.

中文翻译：

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血管内光声成像。

血管内光声 (IVPA) 成像是一种基于导管的微创成像方式，能够提供动脉壁的高分辨率光学吸收图。与血管内超声 (IVUS) 成像相结合，IVPA 和 IVUS 成像组合可用于检测和表征在动脉内壁中积聚的动脉粥样硬化斑块。在本文中，我们介绍并讨论了动脉粥样硬化联合 IVPA/IVUS 成像的各种代表性应用，包括评估动脉粥样硬化斑块的组成、斑块内巨噬细胞的成像以及与斑块形成和发展相关的生物标志物的分子成像。此外，还展示了使用 IVPA 和 IVUS 成像对冠状动脉支架进行成像。此外，