The proper communication between organelles is essential for many aspects of eukaryotic life. The coordination of nuclear and cytoplasmic activities in particular is of pivotal importance and depends on transport in and out of the nucleus. The material which translocates through nuclear pores is diverse; it includes numerous proteins, RNAs and large ribonucleoprotein complexes like ribosomal subunits. To ensure the correct nucleocytoplasmic distribution of these components, appropriate mechanisms have to be in place which control traffic across the nuclear envelope. A growing number of studies support the notion that transport through nuclear pore complexes is intimately linked to cell physiology. As such, it has become evident that changes in the cellular environment, either by externally applied stress, aging or disease, alter nuclear traffic. Due to the progress made in the past few years, we are now beginning to understand these processes at the molecular level. Thus, the concept emerges that stress or disease conditions correlate with signaling events which aim at the nuclear transport apparatus. Here, we summarize results from recent publications that provide evidence for the hypothesis that changes in cell physiology modulate nuclear traffic by targeting multiple transport factors. We propose that this traffic control is at least in part mediated by specific signaling events.

中文翻译：

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核孔交通管制

细胞器之间的适当交流对于真核生物的许多方面都是必不可少的。核和细胞质活动的协调尤其是至关重要的，并且取决于进出细胞核的运输。通过核孔易位的物质多种多样；它包括许多蛋白质、RNA 和大型核糖核蛋白复合物，如核糖体亚基。为了确保这些成分的正确核质分布，必须建立适当的机制来控制穿过核膜的交通。越来越多的研究支持通过核孔复合物的运输与细胞生理学密切相关的观点。因此，很明显，细胞环境的变化，无论是外部施加的压力、衰老还是疾病，都会改变核交通。由于过去几年取得的进展，我们现在开始在分子水平上了解这些过程。因此，出现压力或疾病状况与针对核运输装置的信号事件相关的概念。在这里，我们总结了最近出版物的结果，这些结果为细胞生理学的变化通过针对多种运输因子调节核运输的假设提供了证据。我们建议这种交通控制至少部分是由特定的信号事件介导的。我们总结了最近出版物的结果，这些结果为细胞生理学的变化通过靶向多种运输因子调节核运输的假设提供了证据。我们建议这种交通控制至少部分是由特定的信号事件介导的。我们总结了最近出版物的结果，这些结果为细胞生理学的变化通过靶向多种运输因子调节核运输的假设提供了证据。我们建议这种交通控制至少部分是由特定的信号事件介导的。