Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L(1)), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L(2)) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.

中文翻译：

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新型有机锡 (IV)-席夫碱复合物：合成、表征、抗菌活性和 DNA 相互作用研究。

四种有机锡 (IV) 与 2-(2-羟基苯亚甲基氨基)异吲哚啉-1,3-二酮 (L(1)) 和 4-(4-羟基-3-甲氧基苯亚甲基氨基-N-(嘧啶-2-基)苯磺酰胺的复合物(L(2)) 被合成并通过分析和光谱研究进行了很好的表征。合成的化合物通过圆盘扩散法测试了抗菌活性。复合物 1 和 3 与 CT-DNA 的 DNA 结合已用吸收光谱法进行，这表明这两种复合物都是 CT-DNA 的强力结合物。此外，使用琼脂糖凝胶电泳研究了复合物 1 和 3 与质粒 DNA (pUC19) 的核酸酶活性。与复合物相比，复合物 1 可以作为有效的 DNA 切割剂3 在生理条件下产生切口形式的 DNA 在不存在和存在氧化剂的情况下运行凝胶。