Tissue Optical Clearing Devices (TOCDs) have been shown to increase light transmission through mechanically compressed regions of naturally turbid biological tissues. We hypothesize that zones of high compressive strain induced by TOCD pins produce localized water displacement and reversible changes in tissue optical properties. In this paper, we demonstrate a novel combined mechanical finite element model and optical Monte Carlo model which simulates TOCD pin compression of an ex vivo porcine skin sample and modified spatial photon fluence distributions within the tissue. Results of this simulation qualitatively suggest that light transmission through the skin can be significantly affected by changes in compressed tissue geometry as well as concurrent changes in tissue optical properties. The development of a comprehensive multi-domain model of TOCD application to tissues such as skin could ultimately be used as a framework for optimizing future design of TOCDs.

中文翻译：

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结合有限元和蒙特卡罗模拟的局部机械压缩组织光学清除参数研究

组织光学清除装置 (TOCD) 已被证明可以增加通过自然混浊生物组织的机械压缩区域的光传输。我们假设由 TOCD 针引起的高压缩应变区域会产生局部水置换和组织光学特性的可逆变化。在本文中，我们展示了一种新的组合机械有限元模型和光学蒙特卡罗模型，该模型模拟了体外猪皮肤样本的 TOCD 针压缩和组织内的修改空间光子通量分布。这种模拟的结果定性地表明，通过皮肤的光传输会受到压缩组织几何形状的变化以及组织光学特性的同时变化的显着影响。