Soft polymeric nanomaterials were synthesized by template-assisted method involving condensation of the poly(ethylene oxide)-b-polycarboxylate anions by metal ions into core-shell block ionomer complex micelles followed by chemical cross-linking of the polyion chains in the micelle cores. The resulting materials represent nanogels and are capable of swelling in a pH-dependent manner. The structural determinants that guide the self-assembly of the initial micelle templates and the swelling behavior of the cross-linked micelles include the block ionomer structure, the chemical nature of metal ions, the structure of the cross-links and the degree of cross-linking. The application of these materials for loading and release of a drug, cisplatin, is evaluated. These cross-linked block ionomer micelles have promise for delivery of pharmaceutical agents.

中文翻译：

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用于药物递送的具有交联核的封闭离聚物复合胶束。

软聚合物纳米材料是通过模板辅助方法合成的，包括聚（环氧乙烷）-b-聚羧酸根阴离子与金属离子缩合成核-壳嵌段离聚物复合胶束，然后对胶束核中的聚离子链进行化学交联。所得材料代表纳米凝胶，并且能够以依赖于 pH 的方式溶胀。指导初始胶束模板自组装和交联胶束溶胀行为的结构决定因素包括嵌段离聚物结构、金属离子的化学性质、交联结构和交联度。链接。评估了这些材料在药物顺铂的装载和释放方面的应用。这些交联的嵌段离聚物胶束有望用于递送药剂。