The aim of this study was to determine whether the bone-morphogenetic proreins-2 (BMP-2) or-7 (BMP-7) levels in follicular fluid (FF) are associated with success in oocyte fertilization during assisted reproductive technology (ART) treatment. Twenty-four cycles in 24 patients who underwent oocyte retrieval in Sugiyama clinic were included in this retrospective study. The patients were divided into two groups according to the success or failure of fertilization. FF samples were obtained from a single follicle in each patient, and the levels of BMP-2, BMP-7, Anti-Müllerian hormone (AMH), estradiol and progesterone from FF were measured, and evaluated in relation to the ART outcomes. The BMP-2 levels correlated positively with the AMH levels in FF (r ² = 0.4928), but there was no statistically significant difference between BMP-7 and AMH levels. The BMP-2 and BMP-7 levels had no relation with either progesterone or estradiol levels, but BMP-2 levels in the fertilized group were significantly higher than those in the unfertilized group (P < 0.05). The BMP-2 levels in FF positively correlated with the AMH levels in FF, and those in the fertilized group were significantly higher than in the unfertilized group. Therefore, the BMP-2 levels in FF could be a predictive marker for fertilization.

中文翻译：

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骨形态发生蛋白 2 可能是辅助生殖技术中卵母细胞受精成功的良好预测指标。

本研究的目的是确定卵泡液 (FF) 中的骨形态发生蛋白原-2 (BMP-2) 或-7 (BMP-7) 水平是否与辅助生殖技术 (ART) 期间卵母细胞受精的成功有关治疗。本回顾性研究包括在杉山诊所接受取卵的 24 名患者的 24 个周期。根据受精成功与否将患者分为两组。从每位患者的单个卵泡中获取 FF 样本，并测量来自 FF 的 BMP-2、BMP-7、抗苗勒管激素 (AMH)、雌二醇和黄体酮的水平，并评估与 ART 结果的关系。BMP-2 水平与 FF 中的 AMH 水平呈正相关（r ²= 0.4928)，但 BMP-7 和 AMH 水平之间没有统计学显着差异。BMP-2和BMP-7水平与孕酮和雌二醇水平无关，但受精组BMP-2水平显着高于未受精组（P < 0.05）。FF中BMP-2水平与FF中AMH水平呈正相关，受精组显着高于未受精组。因此，FF 中的 BMP-2 水平可能是受精的预测标志物。