Supramolecular nanostructures assembled by polymeric amphiphiles have been intensively studied during the last two decades. Such nanocarriers may be engineered to possess on-demand bio-responsitivity for the prevention, diagnosis, and treatment of human diseases. The successful development of several nanoassembly-based polymer therapeutics further encouraged scientists to develop nano-vehicles to achieve controlled release, enhanced efficacy, improved specificity and reduced toxicity. Different from the abundant existing literatures on the hydrophobically or electrostatically driven self-assemblies and their therapeutic applications, this article reviews host-guest interaction mediated nanoassemblies, especially those constructed using cyclodextrins as the host entities. The excellent biocompatibility, complexation capacity, and chemical-sensitivity of cyclodextrin make cyclodextrin-containing polymers attractive to construct host-guest nanoassemblies. Such nanocarriers may be advantageous also because of the broad availability of cyclodextrins, their flexibility for structure/property modulation and their chemical-responsive characteristics.

中文翻译：

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使用含环糊精的亲水聚合物介导的主客体相互作用及其生物医学应用


在过去的二十年中，由聚合两亲物组装的超分子纳米结构得到了深入研究。这种纳米载体可以被设计为具有用于预防、诊断和治疗人类疾病的按需生物响应性。几种基于纳米组装的聚合物疗法的成功开发进一步鼓励科学家开发纳米载体以实现控释、增强疗效、提高特异性和降低毒性。与现有大量关于疏水或静电驱动的自组装体及其治疗应用的文献不同，本文回顾了主客体相互作用介导的纳米组装体，特别是那些使用环糊精作为主体实体构建的纳米组装体。环糊精优异的生物相容性、络合能力和化学敏感性使得含环糊精的聚合物对于构建主客体纳米组件具有吸引力。由于环糊精的广泛可用性、其结构/性质调节的灵活性及其化学响应特性，此类纳米载体可能是有利的。