Abstract Buzaianu and Chen apply strong curtailment to modify the two-stage select-and-test clinical trial design proposed by Thall et al. (1988). The modification reduces the expected sample size while maintaining overall power but requires continuous monitoring in stage 1. I will review the history of this type of design and discuss practical issues related to the use of strong curtailment that arise in trial conduct.

中文翻译：

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Elena M. Buzaianu 和 Pinyuen Chen 关于“比较临床试验缩减的混合选择和测试程序”的讨论

摘要 Buzaianu 和 Chen 应用强缩减来修改 Thall 等人提出的两阶段选择和测试临床试验设计。(1988)。修改减少了预期的样本量，同时保持了整体功效，但需要在第 1 阶段进行持续监测。我将回顾此类设计的历史，并讨论与试验实施中出现的使用强缩减相关的实际问题。