ABSTRACT Dual diagnosis is a problem of tremendous depth and scope, spanning many classes of mental disorders and addictive drugs. Animal models of psychiatric disorders studied in addiction paradigms suggest a unitary nature of mental illness and addiction vulnerability both on the neurocircuit and clinical-behavioral levels. These models provide platforms for exploring the interactive roles of biological, environmental and developmental factors on neurocircuits commonly involved in psychiatric and addiction diseases. While suggestive of the artifice of segregated research, training, and clinical cultures between psychiatric and addiction fields, this research may lead to more parsimonious, integrative and preventative treatments for dual diagnosis.

中文翻译：

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双重诊断的动物模型和神经回路

摘要 双重诊断是一个具有极大深度和广度的问题，涵盖了许多类别的精神障碍和成瘾药物。在成瘾范式中研究的精神疾病动物模型表明，精神疾病和成瘾脆弱性在神经回路和临床行为水平上具有统一的性质。这些模型为探索生物、环境和发育因素对通常涉及精神疾病和成瘾疾病的神经回路的交互作用提供了平台。虽然暗示了精神病学和成瘾领域之间分离研究、培训和临床文化的技巧，但这项研究可能会导致双重诊断的更简约、综合和预防性治疗。