Arteries exhibit a remarkable ability to adapt in response to sustained alterations in haemodynamic loading, to heal in response to injuries, and to compensate in response to diverse disease conditions. Nevertheless, such compensatory adaptations are limited and many vascular disorders, if untreated, lead to significant morbidity or mortality. Parallel advances in vascular biology, medical imaging, biomechanics and computational methods promise to provide increased insight into many arterial diseases, including intracranial aneurysms. In particular, although it may be possible to identify useful clinical correlations between either the blood flow patterns within or the shape of aneurysms and their rupture-potential, our ultimate goal should be to couple studies of haemodynamics with those of wall mechanics and the underlying mechanobiology so that we can understand better the mechanisms by which aneurysms develop, enlarge, and rupture and thereby identify better methods of treatment. This article presents one such approach to fluid-solid-growth (FSG) modelling of intracranial aneurysms.

中文翻译：

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将血流动力学与血管壁力学和力学生物学相结合来了解颅内动脉瘤


动脉表现出显着的能力，能够适应血流动力学负荷的持续变化、响应损伤而愈合，以及响应不同的疾病状况而进行代偿。然而，这种代偿性适应是有限的，许多血管疾病如果不治疗，会导致显着的发病率或死亡率。血管生物学、医学成像、生物力学和计算方法的并行进步有望为包括颅内动脉瘤在内的许多动脉疾病提供更多的见解。特别是，尽管有可能确定动脉瘤内的血流模式或动脉瘤的形状与其破裂潜力之间有用的临床相关性，但我们的最终目标应该是将血流动力学研究与壁力学和基础力学生物学研究结合起来这样我们就可以更好地了解动脉瘤发生、扩大和破裂的机制，从而找到更好的治疗方法。本文介绍了一种颅内动脉瘤的液固生长 (FSG) 建模方法。