Microfluidic reactors exhibit intrinsic advantages of reduced chemical consumption, safety, high surface-area-to-volume ratios, and improved control over mass and heat transfer superior to the macroscopic reaction setting. In contract to a continuous-flow microfluidic system composed of only a microchannel network, an integrated microfluidic system represents a scalable integration of a microchannel network with functional microfluidic modules, thus enabling the execution and automation of complicated chemical reactions in a single device. In this review, we summarize recent progresses on the development of integrated microfluidics-based chemical reactors for (i) parallel screening of in situ click chemistry libraries, (ii) multistep synthesis of radiolabeled imaging probes for positron emission tomography (PET), (iii) sequential preparation of individually addressable conducting polymer nanowire (CPNW), and (iv) solid-phase synthesis of DNA oligonucleotides. These proof-of-principle demonstrations validate the feasibility and set a solid foundation for exploring a broad application of the integrated microfluidic system.

中文翻译：

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集成微流控反应器

微流控反应器表现出比宏观反应设置更低的化学消耗、安全性、高表面积与体积比以及改进的质量和传热控制的固有优势。与仅由微通道网络组成的连续流微流体系统相比，集成微流体系统代表了微通道网络与功能微流体模块的可扩展集成，从而能够在单个设备中执行和自动化复杂的化学反应。在这篇综述中，我们总结了基于集成微流体的化学反应器开发的最新进展，用于（i）原位点击化学库的并行筛选，（ii）用于正电子发射断层扫描（PET）的放射性标记成像探针的多步合成，（iii） ) 单独可寻址导电聚合物纳米线 (CPNW) 的连续制备，以及 (iv) DNA 寡核苷酸的固相合成。这些原理验证演示验证了可行性，并为探索集成微流控系统的广泛应用奠定了坚实的基础。