Much recent evidence suggests that bone cells sense their mechanical environment via interstitial fluid flow. In this review, we summarize theoretical and experimental approaches to quantify fluid and solute transport in bone, starting with the early investigations of fluid shear stress applied to bone cells. The pathways of bone interstitial fluid and solute movement are high-lighted based on recent theoretical models, as well as a new generation of tracer experiments that have clarified and refined the structure and function of the osteocyte pericellular matrix. Then we trace how the fluid-flow models for mechanotransduction have evolved as new ultrastructural features of the osteocyte lacunar-canalicular porosity have been identified and how more recent in vitro fluid-flow and cell-stretch experiments have helped elucidate at the molecular level the possible pathways for cellular excitation in bone.

中文翻译：

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骨中的流体和溶质转运：流动诱导的机械转导

最近的许多证据表明，骨细胞通过间质液流动感知其机械环境。在这篇综述中，我们总结了量化骨骼中流体和溶质转运的理论和实验方法，首先是对应用于骨细胞的流体剪切应力的早期研究。基于最近的理论模型以及阐明和完善骨细胞周围基质结构和功能的新一代示踪实验，突出了骨间质液和溶质运动的途径。