Quality of life (QOL) is an important clinical endpoint, but it remarkably varies in patients with similar neurological conditions. This study explored the role of spirituality (i.e., the complex of personal transcendence, connectedness, purpose, and values) in determining QOL in chronic neurological disorders.~Seventy-two patients with epilepsy, brain tumours or ischemic or immune-mediate brain damage compiled inventories for QOL (WHOQOL 100), spirituality (Spiritual, Religious and Personal Beliefs, WHOSRPB), depression (Beck Depression Inventory, BDI), anxiety (State-Trait Anxiety Inventory, STAI), and cognitive self-efficacy (Multiple Ability Self-Report Questionnaire, MASQ) and underwent neuropsychological testing. With respect to 45 healthy controls, the patients reported worse QOL, with no difference between the four patient subgroups. Factor analyses of the WHOSRPB, STAI, and BDI scores and of the MASQ and neuropsychological test scores yielded four (Personal Meaning, Inner Energy, Awe and Openness, Mood) and three factors (Control Functions, Cognition, Memory), respectively. Mood, Cognition, Inner Energy, schooling, and subjective health status correlated with the WHOQOL scores, but at regression analysis only Mood and Inner Energy predicted QOL. This suggests that spirituality, as a personal dimension distinct from mood, contributes to determine QOL. A multidimensional assessment of QOL, including personal facets, may explain differences between patients with chronic neurological disorders.

中文翻译：

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关于慢性神经系统疾病生活质量的个人方面。

生活质量 (QOL) 是一个重要的临床终点，但它在具有相似神经系统疾病的患者中存在显着差异。本研究探讨了灵性（即个人超越性、连通性、目的和价值观的复合体）在决定慢性神经系统疾病 QOL 中的作用。~72 名癫痫、脑肿瘤或缺血性或免疫介导的脑损伤患者汇编生活质量（WHOQOL 100）、灵性（精神、宗教和个人信仰，WHOSRPB）、抑郁（贝克抑郁量表，BDI）、焦虑（状态-特质焦虑量表，STAI）和认知自我效能（多能力自我）的清单报告问卷，MASQ）并接受神经心理学测试。对于 45 名健康对照，患者报告的 QOL 较差，四个患者亚组之间没有差异。WHOSRPB、STAI 和 BDI 分数以及 MASQ 和神经心理学测试分数的因素分析分别产生了四个（个人意义、内在能量、敬畏和开放、情绪）和三个因素（控制功能、认知、记忆）。情绪、认知、内在能量、学校教育和主观健康状况与 WHOQOL 分数相关，但在回归分析中，只有情绪和内在能量可以预测 QOL。这表明，作为与情绪不同的个人维度，灵性有助于决定 QOL。QOL 的多维评估，包括个人方面，可以解释慢性神经系统疾病患者之间的差异。情绪）和三个因素（控制功能、认知、记忆）。情绪、认知、内在能量、学校教育和主观健康状况与 WHOQOL 分数相关，但在回归分析中，只有情绪和内在能量可以预测 QOL。这表明，作为与情绪不同的个人维度，灵性有助于决定 QOL。QOL 的多维评估，包括个人方面，可以解释慢性神经系统疾病患者之间的差异。情绪）和三个因素（控制功能、认知、记忆）。情绪、认知、内在能量、学校教育和主观健康状况与 WHOQOL 分数相关，但在回归分析中，只有情绪和内在能量可以预测 QOL。这表明，作为与情绪不同的个人维度，灵性有助于决定 QOL。QOL 的多维评估，包括个人方面，可以解释慢性神经系统疾病患者之间的差异。