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Flagellated Magnetotactic Bacteria as Controlled MRI-trackable Propulsion and Steering Systems for Medical Nanorobots Operating in the Human Microvasculature
The International Journal of Robotics Research ( IF 7.5 ) Pub Date : 2009-04-01 , DOI: 10.1177/0278364908100924
Sylvain Martel 1 , Mahmood Mohammadi , Ouajdi Felfoul , Zhao Lu , Pierre Pouponneau
Affiliation  

Although nanorobots may play critical roles for many applications in the human body, such as targeting tumoral lesions for therapeutic purposes, miniaturization of the power source with an effective onboard controllable propulsion and steering system have prevented the implementation of such mobile robots. Here, we show that the flagellated nanomotors combined with the nanometer-sized magnetosomes of a single magnetotactic bacterium can be used as an effective integrated propulsion and steering system for devices, such as nanorobots, designed for targeting locations only accessible through the smallest capillaries in humans while being visible for tracking and monitoring purposes using modern medical imaging modalities such as magnetic resonance imaging. Through directional and magnetic field intensities, the displacement speeds, directions, and behaviors of swarms of these bacterial actuators can be controlled from an external computer.

中文翻译:

鞭毛趋磁细菌作为在人体微血管中运行的医用纳米机器人的可控 MRI 可追踪推进和转向系统

尽管纳米机器人可能在人体的许多应用中发挥关键作用,例如针对治疗目的的肿瘤病变,但具有有效的机载可控推进和转向系统的电源的小型化阻止了这种移动机器人的实施。在这里,我们展示了带鞭毛的纳米马达与单个趋磁细菌的纳米大小的磁小体相结合,可用作纳米机器人等设备的有效集成推进和转向系统,这些设备设计用于定位只能通过人类最小毛细血管进入的位置同时使用现代医学成像方式(例如磁共振成像)进行跟踪和监控时可见。通过方向和磁场强度,位移速度、方向、
更新日期:2009-04-01
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