The purpose of this study was to evaluate whether the mRNA expression profiles of three genes (PRMT1, DDAH2 and NOS3) are related to ADMA metabolism and signalling, and the potential relationships with anthropometrical, biochemical, lifestyle and inflammatory indicators in healthy young adults. An emphasis on the putative effect of different mRNA expression on cardiovascular risk-related features was paid. Anthropometrical measurements as well as lifestyle features were analyzed in 120 healthy young adults. Fasting blood samples were collected for the measurement of glucose and lipid profiles as well as the concentrations of selected inflammatory markers. Profiles of mRNA expression were assessed for PRMT1, DDAH2 and NOS3 genes from peripheral blood mononuclear cells. Regarding inflammatory biomarkers, DDAH2 was inversely associated with IL-6 and TNF-α. Moreover, subjects in the highest quintile of DDAH2 mRNA expression showed a reduced risk to have higher values of waist circumference, and to be more prone to show higher values of HDL-c. Interestingly, DDAH2 gene expression seemed to be related with some anthropometrical, biochemical, lifestyle and inflammatory indicators linked to cardiovascular risk in apparently healthy young adults, emerging as a potential disease marker.

中文翻译：

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DDAH2 mRNA 表达与健康年轻人的一些心血管风险相关特征呈负相关。

本研究的目的是评估三个基因（PRMT1、DDAH2 和 NOS3）的 mRNA 表达谱是否与 ADMA 代谢和信号传导有关，以及与健康年轻人的人体测量学、生化、生活方式和炎症指标的潜在关系。强调了不同 mRNA 表达对心血管风险相关特征的推定影响。分析了 120 名健康年轻人的人体测量数据以及生活方式特征。收集空腹血样用于测量葡萄糖和脂质分布以及所选炎症标志物的浓度。评估了来自外周血单核细胞的 PRMT1、DDAH2 和 NOS3 基因的 mRNA 表达谱。关于炎症生物标志物，α。此外，DDAH2 mRNA 表达最高五分之一的受试者显示出腰围值较高的风险降低，并且更倾向于显示较高的 HDL-c 值。有趣的是，DDAH2 基因表达似乎与一些与明显健康的年轻人的心血管风险相关的人体测量学、生化、生活方式和炎症指标有关，并成为潜在的疾病标志物。