Cardiovascular disease is the leading cause of global mortality, with coronary heart disease (CHD) its major manifestation. Although inflammation, the body’s response to noxious stimuli, is implicated in several stages of CHD development, the relevance of circulating levels of markers of inflammation to CHD risk remains uncertain. This review summarizes available epidemiological evidence for four emerging inflammatory markers implicated in CHD (fibrinogen, C-reactive protein, lipoprotein-associated phospholipase A₂ and interleukin-6); considers their likely utility in cardiovascular risk prediction; and outlines areas of outstanding uncertainty.

中文翻译：

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炎症和冠心病风险的标志物。

心血管疾病是全球死亡的主要原因，冠心病（CHD）是其主要表现。尽管炎症，身体对有害刺激的反应，与 CHD 发展的几个阶段有关，但炎症标志物的循环水平与 CHD 风险的相关性仍然不确定。本综述总结了与 CHD 相关的四种新兴炎症标志物（纤维蛋白原、C 反应蛋白、脂蛋白相关磷脂酶 A ₂和白细胞介素 6）的现有流行病学证据；考虑它们在心血管风险预测中的可能效用；并概述了突出的不确定性领域。