A total of 306 boars (108 Large White and 198 Landrace) were genotyped for 52 candidate SNPs to determine which of the polymorphisms influence growth rate, meat content and selection index. The effects of SNPs were estimated by a mixed linear model including a random additive polygenic animal effect, fixed effects of SNPs including additive, and pairwise additive-by-additive epistases, year*season of birth, breed and RYR1 genotype. In order to estimate all possible pairwise SNP combinations without overparameterising the model a stochastic approach was adopted. A total of 1 350 replications of the model were generated, each containing five randomly selected SNPs. The final estimates of the fixed effects of the model equaled an average out of the replications. The hypothesis of a nonzero effect of SNP was tested by the Wald test. Among 4 257 estimates calculated, many significant (P<0.01), but mostly minor effects (below 1 phenotypic standard deviation) were recorded. The selected SNPs will be further investigated to determine which may be used in MAS.

中文翻译：

---

19 个猪 SNP 对生长速度、肉含量和选择指数的叠加效应。

对总共 306 头公猪（108 头大白猪和 198 头长白猪）进行了 52 个候选 SNP 的基因分型，以确定哪些多态性会影响生长速度、肉含量和选择指数。SNP 的影响通过混合线性模型进行评估，该模型包括随机加性多基因动物效应、SNP 的固定效应（包括加性和成对加性上位性）、出生年份 * 季节、品种和 RYR1 基因型。为了在不过度参数化模型的情况下估计所有可能的成对 SNP 组合，采用了一种随机方法。总共生成了 1 350 个模型重复，每个重复包含五个随机选择的 SNP。模型固定效应的最终估计等于重复的平均值。通过 Wald 检验检验了 SNP 非零效应的假设。在计算的 4 257 个估计值中，记录了许多显着（P < 0.01），但大多数影响较小（低于 1 表型标准偏差）。将进一步研究选定的 SNP，以确定哪些可用于 MAS。