A male patient with primary AL amyloidosis who had been suffering from systemic lymphadenopathy with IgMkappa-type M-proteinemia received two courses of VAD and high-dose melphalan with in vivo elimination of CD20(+) cells using rituximab followed by autologous peripheral blood stem cell transplantation. Four years after complete hematological remission he showed marked reduction in size of the amyloid-laden lymph nodes. Deposits of AL amyloid may regress from the tissue if the chemotherapy succeeds in persistent inhibition of the production of amyloidogenic immunoglobulin light chains.

中文翻译：

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IgM相关性AL淀粉样变性患者接受强化化疗后淀粉样蛋白淋巴结病明显缩小。

一名患有系统性淋巴结肿大伴IgMkappa型M蛋白血症的原发性AL淀粉样变性的男性患者接受了两个疗程的VAD和大剂量美法仑，使用利妥昔单抗随后体内自体外周血干细胞来体内清除CD20（+）细胞移植。血液学完全缓解后的四年，他的淀粉样蛋白淋巴结大小明显减少。如果化学疗法成功持续抑制淀粉样蛋白生成的免疫球蛋白轻链的产生，则AL淀粉样蛋白的沉积可能会从组织中消退。