Cerebrovascular diseases (CVD) are dysfunctions of the brain, resulting from diseases of blood vessels supplying the brain. Atherosclerosis is one of the major underlying causes of CVD, in which inflammation plays a crucial role. One of the inflammatory mechanisms contributing to atherogenesis is the activation of monocytes and macrophages, which could be mediated by the bacterial endotoxin lipopolysaccharide (LPS) via its receptor CD14. The C260T (rs2569190) single-nucleotide polymorphism (SNP) in the promoter region of theCD14 gene was implicated in CVD. To assess the role of this SNP in CVD, a comprehensive meta-analysis of the available genetic data was conducted. All the case-control association studies evaluating the role ofCD14 C260T in CVD were identified. Of these, 7 studies (comprising a total of 1488 patients and 1600 control subjects) were included in this meta-analysis. To measure the strength of genetic association for the gene variant, the odds ratios (ORs) were calculated using both fixed and random effects for comparisons of the alleles, the genotypes, and the dominant and recessive genotype models. The results showed there was no significant association between the T allele of C260T and the risk of CVD under the fixed effects model, OR = 0.99 (95% CI (0.89, 1.09)),P = 0.84; or the random effects model, OR = 0.99 (95% CI (0.88,1.11)),P = 0.83. Similar results were obtained for the homozygotes and the dominant and recessive models. In conclusion, the results of this meta-analysis suggest theCD14 C260T polymorphism is not a risk factor for CVD. However, more studies in ethnically varied populations are needed to evaluate in a reliable manner the role of this SNP in CVD susceptibility.

中文翻译：

---

CD14 C260T 启动子多态性和脑血管疾病风险：荟萃分析。

脑血管疾病 (CVD) 是大脑功能障碍，由供应大脑的血管疾病引起。动脉粥样硬化是 CVD 的主要潜在原因之一，其中炎症起着至关重要的作用。导致动脉粥样硬化的炎症机制之一是单核细胞和巨噬细胞的激活，这可能由细菌内毒素脂多糖 (LPS) 通过其受体 CD14 介导。CD14基因启动子区域的 C260T (rs2569190) 单核苷酸多态性 (SNP) 与CVD 相关。为了评估该 SNP 在 CVD 中的作用，对可用遗传数据进行了全面的荟萃分析。所有评估CD14作用的病例对照关联研究CVD中的C260T被鉴定。其中，7 项研究（包括总共 1488 名患者和 1600 名对照受试者）被纳入该荟萃分析。为了测量基因变异的遗传关联强度，使用固定和随机效应计算比值比 (OR)，以比较等位基因、基因型以及显性和隐性基因型模型。结果显示，固定效应模型下C260T的T等位基因与CVD风险无显着相关性，OR=0.99（95%CI（0.89，1.09）），P =0.84；或随机效应模型，OR = 0.99（95% CI (0.88,1.11)），P = 0.83。对于纯合子以及显性和隐性模型，获得了类似的结果。总之，这项荟萃分析的结果表明CD14 C260T 多态性不是 CVD 的危险因素。然而，需要在不同种族的人群中进行更多研究，以可靠的方式评估这种 SNP 在 CVD 易感性中的作用。