About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel approaches are needed to prevent or alleviate epileptogenic process after various types of brain injuries. The use of cell transplants as factories to produce endogeneous anticonvulsants or as bricks to repair abnormal ictogenic and epileptogenic neuronal circuits has generated hope that cell-based therapies could become a novel therapeutic category in the treatment arsenal of epilepsy. Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy.

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评论：基于细胞的癫痫治疗前景。

大约 30% 的癫痫患者对现有的抗癫痫药物没有反应。除了抑制癫痫发作，还需要新的方法来预防或减轻各种类型的脑损伤后的癫痫发生过程。使用细胞移植作为生产内源性抗惊厥药的工厂或作为修复异常致发性和致痫性神经元回路的砖块，产生了希望，即基于细胞的疗法可能成为癫痫治疗库中的一种新型治疗方法。在此，我们总结了基于细胞的疗法在治疗癫痫方面的现状和未来前景。