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Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients.
Disease Markers Pub Date : 2009 , DOI: 10.3233/dma-2009-0603
Petra Bohanec Grabar 1 , Dussan Logar , Matija Tomsic , Blaz Rozman , Vita Dolzan
Affiliation  

Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor necrosis factor-alpha (TNFA) and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857T and NOS2A (CCTTT)n polymorphisms in 327 RA patients. Carriers of CAT -262T and TNFA -308A allele had lower mean disease activity score of 28 joint count (DAS28) values than patients with CAT -262CC and TNFA -308GG genotypes (p = 0.014 and p = 0.046, respectively). Patients with the combination of CAT -262T and TNFA -308A allele had lower mean DAS28 values and a higher probability for low disease activity than non-carriers (p = 0.003, OR = 3.585, 95% CI = 1.538–8.357). Our results suggest that CAT and TNFA polymorphisms alone and in combination influence the activity of RA.

中文翻译:

改变氧化应激的遗传多态性与类风湿性关节炎患者的疾病活动有关。

活性氧和氮物质参与类风湿性关节炎 (RA) 的病理学。编码超氧化物歧化酶(SOD2 和 SOD3)、过氧化氢酶 (CAT)、肿瘤坏死因子-α (TNFA) 和诱导型 NO 合酶 (NOS2A) 的基因的多态性可能会影响 RA 活性。我们确定了 327 名 RA 患者的SOD2 Ala-9Val、SOD3 Arg213Gly、CAT C-262T、TNFA G-308A、TNFA C-857T 和 NOS2A (CCTTT) n多态性。CAT -262T 和 TNFA -308A 等位基因携带者的 28 个关节计数 (DAS28) 值的平均疾病活动评分低于 CAT -262CC 和 TNFA -308GG 基因型患者(p = 0.014 和p= 0.046,分别)。与非携带者相比,具有 CAT -262T 和 TNFA -308A 等位基因组合的患者具有更低的平均 DAS28 值和更高的低疾病活动概率(p = 0.003,OR = 3.585,95% CI = 1.538–8.357)。我们的结果表明 CAT 和 TNFA 多态性单独和组合影响 RA 的活性。
更新日期:2020-09-25
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