Reactive oxygen and nitrogen species are involved in the pathology of rheumatoid arthritis (RA). Polymorphisms in genes coding for superoxide dismutases (SOD2 and SOD3), catalase (CAT), tumor necrosis factor-alpha (TNFA) and inducible NO synthase (NOS2A) may influence RA activity. We determined SOD2 Ala-9Val, SOD3 Arg213Gly, CAT C-262T, TNFA G-308A, TNFA C-857T and NOS2A (CCTTT)_n polymorphisms in 327 RA patients. Carriers of CAT -262T and TNFA -308A allele had lower mean disease activity score of 28 joint count (DAS28) values than patients with CAT -262CC and TNFA -308GG genotypes (p = 0.014 and p = 0.046, respectively). Patients with the combination of CAT -262T and TNFA -308A allele had lower mean DAS28 values and a higher probability for low disease activity than non-carriers (p = 0.003, OR = 3.585, 95% CI = 1.538–8.357). Our results suggest that CAT and TNFA polymorphisms alone and in combination influence the activity of RA.

中文翻译：

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改变氧化应激的遗传多态性与类风湿性关节炎患者的疾病活动有关。

活性氧和氮物质参与类风湿性关节炎 (RA) 的病理学。编码超氧化物歧化酶（SOD2 和 SOD3）、过氧化氢酶 (CAT)、肿瘤坏死因子-α (TNFA) 和诱导型 NO 合酶 (NOS2A) 的基因的多态性可能会影响 RA 活性。我们确定了 327 名 RA 患者的SOD2 Ala-9Val、SOD3 Arg213Gly、CAT C-262T、TNFA G-308A、TNFA C-857T 和 NOS2A (CCTTT) _n多态性。CAT -262T 和 TNFA -308A 等位基因携带者的 28 个关节计数 (DAS28) 值的平均疾病活动评分低于 CAT -262CC 和 TNFA -308GG 基因型患者（p = 0.014 和p= 0.046，分别）。与非携带者相比，具有 CAT -262T 和 TNFA -308A 等位基因组合的患者具有更低的平均 DAS28 值和更高的低疾病活动概率（p = 0.003，OR = 3.585，95% CI = 1.538–8.357）。我们的结果表明 CAT 和 TNFA 多态性单独和组合影响 RA 的活性。