Although the concepts of secondary injury and neuroprotection after neurotrauma are experimentally well supported, clinical trials of neuroprotective agents in traumatic brain injury or spinal cord injury have been disappointing. Most strategies to date have used drugs directed toward a single pathophysiological mechanism that contributes to early necrotic cell death. Given these failures, recent research has increasingly focused on multifunctional (i.e., multipotential, pluripotential) agents that target multiple injury mechanisms, particularly those that occur later after the insult. Here we review two such approaches that show particular promise in experimental neurotrauma: cell cycle inhibitors and small cyclized peptides. Both show extended therapeutic windows for treatment and appear to share at least one important target.

中文翻译：

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神经创伤的多功能药物治疗。


尽管神经外伤后继发性损伤和神经保护的概念得到了实验的充分支持，但神经保护剂治疗创伤性脑损伤或脊髓损伤的临床试验却令人失望。迄今为止，大多数策略都使用针对导致早期坏死细胞死亡的单一病理生理机制的药物。鉴于这些失败，最近的研究越来越关注针对多种损伤机制的多功能（即多能、多能）药物，特别是针对损伤后发生的损伤机制。在这里，我们回顾了两种在实验性神经创伤中显示出特殊前景的方法：细胞周期抑制剂和小环化肽。两者都显示出更长的治疗窗口，并且似乎具有至少一个共同的重要目标。