The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

中文翻译：

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乙型肝炎病毒感染的免疫病理学。

免疫应答和乙型肝炎病毒（HBV）之间的相互作用在先天免疫和适应性免疫之间协调。抗HBs抗体通过阻断HBV的结合能力来保护宿主。检测到抗-HBc抗体持续存在HBV感染。抗HBe抗体的存在通常与从活动性疾病中恢复有关，并在临床上用作评估对治疗反应的基准。我们的研究表明，在不同的HBV感染状况人群中，分泌的抗HBV免疫球蛋白的亚类模式不同。这些启示可能有助于了解HBV逃逸和持续感染，并制定预防和治疗HBV感染的策略。