The constant threat of a new influenza pandemic, which may be caused by a highly pathogenic avian influenza virus, necessitates the development of a vaccine capable of providing efficient, long-term, and cost-effective protection. Proven avenues for the development of vaccines against seasonal influenza as well as novel approaches have been explored over the past decade. Whereas significant insights are consistently being made, the generation of a highly efficient and cross-protective vaccine against the future pandemic influenza strain remains as the ultimate goal in the field. In this review, we re-examine these efforts and outline the scientific, political, and economic problems that befall this area of biotechnological research.

中文翻译：

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抗大流行性流感病毒疫苗的开发：现状和观点。

高致病性禽流感病毒可能引起新的流感大流行的持续威胁，因此需要开发能够提供有效，长期和具有成本效益的保护的疫苗。在过去的十年中，已经开发出了针对季节性流感的疫苗开发途径以及新颖的方法。尽管不断有重要的见识，但针对未来的大流行性流感病毒株的高效和交叉保护疫苗的产生仍然是该领域的最终目标。在这篇综述中，我们重新审视了这些努力，并概述了属于生物技术研究领域的科学，政治和经济问题。