The aim of present study is to assess DNA integrity on the effect of exposure to a radio frequency (RF) signal from Code Division Multiple Access (CDMA) mobile phones. Whole blood samples from six healthy male individuals were exposed for RF signals from a CDMA mobile phone for 1 h. Alkaline comet assay was performed to assess the DNA damage. The combinative exposure effect of the RF signals and APC at two concentrations on DNA integrity was studied. DNA repair efficiency of the samples was also studied after 2 h of exposure. The RF signals and APC (0.2 μg/ml) alone or in synergism did not have any significant DNA damage as compared to sham exposed. However, univariate analysis showed that DNA damage was significantly different among combinative exposure of RF signals and APC at 0.2 μg/ml (p < 0.05) and at 2 μg/ml (p < 0.02). APC at 2 μg/ml concentration also showed significant damage levels (p < 0.05) when compared to sham exposed. DNA repair efficiency also varied in a significant way in combinative exposure sets (p < 0.05). From these results, it appears that the repair inhibitor APC enhances DNA breaks at 2 μg/ml concentration and that the damage is possibly repairable. Thus, it can be inferred that the in vitro exposure to RF signals induces reversible DNA damage in synergism with APC.

中文翻译：

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CDMA手机射频信号与Aphidicolin联合暴露对DNA完整性的影响

本研究的目的是评估 DNA 完整性对暴露于码分多址 (CDMA) 移动电话的射频 (RF) 信号的影响。来自 6 名健康男性的全血样本暴露于来自 CDMA 移动电话的射频信号 1 小时。进行碱性彗星试验以评估 DNA 损伤。研究了两种浓度的 RF 信号和 APC 的组合暴露对 DNA 完整性的影响。在暴露 2 小时后还研究了样品的 DNA 修复效率。与假暴露相比，单独或协同的 RF 信号和 APC (0.2 μg/ml) 没有任何显着的 DNA 损伤。然而，单变量分析表明，在 0.2 μg/ml (p < 0.05) 和 2 μg/ml (p < 0.02) 的 RF 信号和 APC 组合暴露中，DNA 损伤显着不同。与假暴露相比，2 μg/ml 浓度的 APC 也显示出显着的损伤水平（p < 0.05）。DNA 修复效率在组合暴露组中也有显着差异（p < 0.05）。从这些结果来看，修复抑制剂 APC 似乎在 2 μg/ml 浓度下增强了 DNA 断裂，并且损伤可能是可修复的。因此，可以推断出体外暴露于射频信号与 APC 协同诱导可逆的 DNA 损伤。