The synthesis of a new series of 1β‐methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound III b having an oxime‐pyrrolidine moiety showed the most potent antibacterial activity.

中文翻译：

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新型抗菌剂1β-甲基碳青霉烯衍生物的合成及体外活性

描述了具有吡咯烷和哌啶部分的新系列 1β-甲基碳青霉烯的合成。测试了它们对革兰氏阳性菌和革兰氏阴性菌的体外抗菌活性，并研究了取代基对吡咯烷环的影响。具有肟-吡咯烷部分的特定化合物 III b 显示出最有效的抗菌活性。