Infection of man and animals with parasitic nematodes is recognized as a significant global problem (McLeod in Int J Parasitol 25(11):1363-1367, 1994; Hotez et al. in N Engl J Med 357(10):1018-1027, 2007). At present control of these infections relies primarily on chemotherapy. There are a limited number of classes of anthelmintic compounds and the majority of these act on ion-channels of the parasite (Martin et al. in Parasitology 113:S137-S156, 1996). In this report, we describe electrophysiological recording techniques as applied to parasitic nematodes. The aim of this report is: (1) to promote the study of ion channels in nematodes to help further the understanding of antinematodal drug action; (2) to describe our recording equipment and experimental protocols; and (3) provide some examples of the information to be gleaned from this approach and how it can increase our understanding of these important pathogens.

中文翻译：

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寄生线虫肌肉的电生理记录。

寄生线虫感染人和动物被认为是一个重大的全球性问题（McLeod in Int J Parasitol 25(11):1363-1367, 1994; Hotez et al. in N Engl J Med 357(10):1018-1027, 2007）。目前对这些感染的控制主要依赖于化疗。抗蠕虫化合物种类有限，其中大部分作用于寄生虫的离子通道（Martin 等，Parasitology 113：S137-S156，1996）。在本报告中，我们描述了应用于寄生线虫的电生理记录技术。本报告的目的是：（1）推动线虫体内离子通道的研究，以帮助进一步了解抗线虫药物的作用；(2) 描述我们的录音设备和实验方案；